Ultram Drug Interactions
There have been rare reports of digoxin toxicity in people taking Ultram. Check with your healthcare provider before combining these medications.
Taking Ultram with linezolid can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous (see Tramadol and Serotonin Syndrome for more information).
Medications That Cause Drowsiness
Combining Ultram with any other medications that cause drowsiness can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking Ultram with such medications. In addition, combining Ultram with some of these medications may increase the risk of seizures or serotonin syndrome.
(Click Tramadol and Serotonin Syndrome and Tramadol and Seizures for a list of medications that can cause these problems when taken with Ultram).
Combining promethazine and Ultram can increase the risk of seizures or other Ultram side effects. Check with your healthcare provider before taking these medications together.
The liver metabolizes Ultram into a substance known as M1, which is responsible for much of the pain-relieving properties of Ultram. Quinidine interferes with the liver's ability to metabolize Ultram into M1, which might possibly make the medication less effective.