Ultracet Drug Interactions

If you combine alcohol, antihistamines, or sleep medications with Ultracet, drug interactions could potentially occur. Some interactions can cause seizures or a group of dangerous symptoms called serotonin syndrome, while others can increase your risk of side effects, such as seizures, drowsiness, confusion, memory loss, or difficulty breathing. Other medications that may lead to Ultracet interactions include antipsychotics, benzodiazepines, antidepressants, and other acetaminophen products.

Ultracet Drug Interactions: An Overview

Ultracet® (tramadol/acetaminophen) can potentially interact with a number of other medications. Many of these interactions can be quite serious. Some of the medicines that may lead to Ultracet interactions include:
  • Alcoholic beverages
  • Antihistamines (including many allergy, sleep, and motion sickness medications)
  • Antipsychotics
  • Barbiturate medications, including (but not limited to):


    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Benzodiazepines, such as:










8 Frequent Pain Syndromes

Ultracet Pain Medication

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