Tapentadol Dosage

With tapentadol, the dosing guidelines are not the same for everyone. The severity of your pain, the type of pain, and your history of opioid use will all play a role in the dosage your healthcare provider prescribes. In most cases, tapentadol is taken every four to six hours, with a typical dose ranging between 50 and 100 mg.

An Introduction to Dosing With Tapentadol

The dose of tapentadol (Nucynta™) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The type and severity of your pain
  • How you respond to the medication
  • Other medications you are taking
  • Other pain medications you have tried
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Tapentadol Dosage for Pain

As with many opioid pain relievers, there is variation in the dosage of tapentadol that can be tolerated and that will effectively relieve pain. The amount will depend on several factors, such as the severity of pain and your history of opioid use (people become tolerant to the effects of opioids over time). In general, typical tapentadol doses range from 50 to 100 mg every four to six hours.
The first day of use, your healthcare provider may recommend increasing your tapentadol dose as soon as one hour after the first dose if it appears that you will need a higher dosage. Amounts higher than 700 mg on the first day or 600 mg on subsequent days have not been studied and are not currently recommended.
If you have liver disease, your healthcare provider may recommend starting with a low dosage, since you may not handle tapentadol as well as normal.
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Tapentadol Drug Information

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