Drug Interactions With Tapentadol

Tramadol
Taking tapentadol with tramadol can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before combining these medications, and call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
Triptans
Combining tapentadol with a triptan can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together, and call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
Tryptophan
Taking tapentadol with tryptophan can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before combining these medications, and call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 

Final Thoughts

It is possible that not all tapentadol drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
 
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