Drug Interactions With Tapentadol

More Details on Drug Interactions With Tapentadol

The following sections explain in detail the potentially negative interactions that can occur when tapentadol is combined with any of the drugs listed above.
 
Linezolid
Taking tapentadol with linezolid can increase the risk of a group of symptoms called serotonin syndrome. These symptoms include:
 
  • Confusion
  • Hallucinations
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
 
Talk to your healthcare provider before taking these medications together, and call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.
 
Medications That Cause Drowsiness
Combining tapentadol with any other medications that cause drowsiness can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking tapentadol with such medications.
 
In addition, combining tapentadol with antidepressants may increase the risk of serotonin syndrome.
 
Monoamine Oxidase Inhibitors (MAOIs)
Taking tapentadol with an MAOI can cause life-threatening reactions. Do not use tapentadol and an MAOI within 14 days of each other.
 
Sibutramine
Taking tapentadol with sibutramine can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before combining these medications, and call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
St. John's Wort
Combining tapentadol with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these products together, and call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
Warning: 10 Hidden Sources of Lactose

Tapentadol Drug Information

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