Skelaxin Interactions

When certain medications are taken with Skelaxin, drug interactions may occur. These interactions could increase your risk of side effects, including drowsiness, confusion, or difficulty breathing. Some of the substances that can lead to negative Skelaxin interactions include alcohol, barbiturates, benzodiazepines, and sleep medications. Make sure to talk to your healthcare provider before taking Skelaxin with any of these medications.

An Overview of Skelaxin Drug Interactions

Skelaxin® (metaxalone) can potentially interact with several other medications. Some of the medicines that may lead to drug interactions with Skelaxin include:
 
  • Alcohol
  • Barbiturates, such as:
 
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
  • Benzodiazepines, such as:
 
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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