Side Effects of Propoxyphene/Acetaminophen

Possible Side Effects of Propoxyphene/Acetaminophen

For many medications, the prescribing information carefully explains the exact percentage of side effects that were seen in clinical trials. However, the prescribing information for almost all older medications (including propoxyphene/acetaminophen) include only vague side effect information, with no percentages provided. Therefore, it can be difficult to know exactly how common (or how rare) the side effects of such medications may be.
Based on this limited information, the most common propoxyphene/acetaminophen side effects include:
  • Dizziness
  • Drowsiness
  • Nausea
  • Vomiting
Other possible side effects include (but are not limited to):

Serious Side Effects

Some side effects with propoxyphene/acetaminophen are potentially serious and should be reported immediately to your healthcare provider. These include, but are not limited to:
  • Hallucinations
  • Unexplained unpleasant feelings (dysphoria) or pleasant feelings (euphoria)
  • The urge to take more propoxyphene/acetaminophen than prescribed or for a non-medical purpose (see Darvocet Addiction)
  • Signs of liver damage, such as:


    • Yellowing of the whites of the eyes or skin (jaundice)
    • Dark urine
    • Upper-right abdominal pain (stomach pain)


  • Signs of kidney damage, such as:


    • Lower back or side pain
    • Bloody or cloudy urine
    • Greatly increased urination
    • Bladder control problems


  • Signs of an allergic reaction, such as:


    • An unexplained rash
    • Itching
    • Hives
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.


5 Common Pain Medication Fears

Propoxyphene/Acetaminophen Drug Information

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