Precautions and Warnings With Propoxyphene/Acetaminophen

Specific Warnings and Precautions for Propoxyphene/Acetaminophen

Warnings and precautions to be aware of prior to taking propoxyphene/acetaminophen include the following:
  • Propoxyphene/acetaminophen contains a narcotic medication and has a significant potential for abuse. It is not a good choice for people who have a history of alcohol or drug abuse (see Darvocet Addiction). Do not take the drug more frequently, longer, or at a higher dose than prescribed. If you feel you may be developing a problem with propoxyphene/acetaminophen, please seek help from your healthcare provider.
  • An overdose (either accidental or intentional) with propoxyphene/acetaminophen can be extremely dangerous. In some cases, an overdose can be lethal within 15 minutes. Be sure to follow your dosage instructions very carefully and do not exceed the recommended amount. Because it is very dangerous in the case of an overdose, this medication should be prescribed cautiously to people with depression or suicidal tendencies (see Darvocet Overdose for more information).
  • Do not drive or operate heavy machinery until you know how propoxyphene/acetaminophen affects you. Your reflexes and reaction times may be significantly affected, even if you feel fine.


  • Make sure your healthcare provider knows if you have lung, liver, kidney, pancreas, or gallbladder problems before you take this medication, as propoxyphene/acetaminophen may not be the best choice for you.


  • Propoxyphene/acetaminophen can potentially interact with several other medications (see Drug Interactions With Propoxyphene/Acetaminophen).
  • Propoxyphene/acetaminophen is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Darvocet and Pregnancy).
  • Propoxyphene/acetaminophen passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Darvocet and Breastfeeding).
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Propoxyphene/Acetaminophen Drug Information

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