Drug Interactions With Propoxyphene/Acetaminophen

There are a number of medications that may cause propoxyphene/acetaminophen drug interactions, including carbamazepine, monoamine oxidase inhibitors, and certain beta blockers. These interactions could increase the drug levels in your blood, perhaps increasing your risk of side effects. To help prevent these drug interactions, make sure to tell your healthcare provider about all other medications you are taking before using the pain reliever.

Propoxyphene/Acetaminophen Interactions: An Overview

Propoxyphene/acetaminophen (Darvocet®) can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with propoxyphene/acetaminophen include:
 

 

 

 

  • Medications that cause drowsiness, including, but not limited to:

 

 

  • Monoamine oxidase inhibitors (MAOIs), including:

 

 

  • Other acetaminophen medications, including many prescription and non-prescription pain relievers, fever reducers, and cough and cold medications
  • Warfarin (Coumadin®, Jantoven®).
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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