Drug Interactions With Propoxyphene/Acetaminophen

Propoxyphene/Acetaminophen Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when propoxyphene/acetaminophen is combined with any of the drugs listed above.
 
Alcohol
You should avoid alcohol while taking propoxyphene/acetaminophen. Alcohol interacts with propoxyphene/acetaminophen, potentially increasing the risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing (see Darvocet and Alcohol for more information).
 
Carbamazepine
Propoxyphene/acetaminophen may increase the level of carbamazepine in your blood, perhaps increasing your risk of side effects of carbamazepine (including dangerous side effects). Your healthcare provider may recommend a different pain medication or decide to decrease your carbamazepine dosage.
 
Certain Beta Blockers
Propoxyphene/acetaminophen may increase the level of certain beta blockers in your blood. This may increase the chance of beta blocker side effects, such as low blood pressure (hypotension) or a low heart rate (bradycardia). Check with your healthcare provider before taking propoxyphene/acetaminophen with one of these beta blockers.
 
CYP3A4 Inhibitors
The propoxyphene component of this medication is metabolized by a certain liver enzyme known as CYP3A4. Some other medications may slow down this enzyme, increasing the level of propoxyphene in the blood. This can be dangerous and may lead to a fatal overdose.
  
Medications That Cause Drowsiness
Combining propoxyphene/acetaminophen with any other medications that cause drowsiness can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Other serious side effects, such as dangerously low blood pressure, may also occur. Talk to your healthcare provider before taking propoxyphene/acetaminophen with such medications.
 
Additionally, combining propoxyphene/acetaminophen with antidepressants may increase the risk of a group of symptoms called serotonin syndrome. These symptoms include confusion, hallucination, fast heartbeat, feeling faint, fever, sweating, muscle spasm, difficulty walking, and diarrhea. Talk to your healthcare provider before taking propoxyphene/acetaminophen with an antidepressant. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
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Propoxyphene/Acetaminophen Drug Information

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