Oxycodone Side Effects

Serious Side Effects

Some side effects with oxycodone are potentially serious and should be reported immediately to your healthcare provider. These include, but are not limited to:
  • The urge to take more oxycodone than prescribed or for a non-medical purpose
  • Falling or unsteadiness
  • Unusual changes in mood or behavior
  • Severe constipation
  • Confusion
  • A slow heart rate (bradycardia)
  • Difficulty passing urine
  • Low blood pressure (hypotension)
  • Slow or irregular breathing
  • Severe drowsiness
  • Seizures
  • Signs of an allergic reaction, such as:


    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing. 


It is common to develop non-allergic itching due to oxycodone. Oxycodone causes a release of histamine, resulting in itching unrelated to any allergy. If you develop itching but no other allergy symptoms, it is unlikely that you are allergic to oxycodone. However, make sure to tell your healthcare provider, as there are medications available to help relieve the itching.

Less Common Side Effects of Oxycodone

There are other, less common oxycodone side effects that can occur. For these side effects, it is difficult to tell whether the side effect is caused by oxycodone or something else.
These less common oxycodone side effects include, but are not limited to:
  • Neck pain
  • Migraines
  • Difficulty swallowing
  • Belching
  • Gas
  • Increased appetite
  • Dehydration
  • Thirst
  • Memory loss (amnesia)
  • Shakiness (tremors)
  • A spinning sensation (vertigo)
  • Voice changes
  • Dry skin
  • Taste changes
  • Missed menstrual periods
  • Decreased sex drive
  • Impotence (also known as erectile dysfunction, or ED)
  • Painful urination or difficulty urinating.
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