Oxycodone Drug Interactions

Several medications can cause potentially dangerous drug interactions with oxycodone, including antihistamines, antipsychotic drugs, and antidepressants. In addition, it is important to avoid alcohol while taking this drug. Problems could occur that may increase your risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Before taking oxycodone, make sure your healthcare provider is aware of any other medications you are taking.

Oxycodone Interactions: An Overview

Oxycodone hydrochloride is a prescription pain medication that can potentially interact with a number of other medications, particularly other medications that cause sedation or drowsiness. Some of the medicines that may lead to drug interactions with oxycodone include, but are not limited to:
 
  • Alcoholic beverages (or other products that contain alcohol)
  • Alvimopan (Entereg®)
  • Antidepressants
  • Antihistamines (including many non-prescription cold, cough, allergy, motion sickness, and sleep medications)
  • Antipsychotic drugs, including (but not limited to):

 

 

  • Barbiturate medications, such as:

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

  • Benzodiazepine sedatives, such as:

 

 

  • Muscle relaxants, such as:

 

 

  • Monoamine oxidase inhibitors (MAOIs), including:

 

 


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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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