Oxycodone Drug Interactions

Oxycodone Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when oxycodone is combined with any of the drugs listed above.
 
Alcohol
You should avoid alcohol while taking oxycodone. Alcohol increases the risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing.
 
Alvimopan
Oxycodone may increase the risk of serious alvimopan side effects. You should not take alvimopan if you have taken oxycodone for each of the past seven days.
 
Antidepressants
Combining antidepressants with oxycodone could increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking oxycodone with an antidepressant, as you may need to be monitored more closely and the dose of your medications may need to be adjusted.
 
Antihistamines
Many antihistamines cause significant drowsiness and can cause serious problems when used in combination with other medications that cause drowsiness, such as oxycodone. Taking an antihistamine with oxycodone may also increase the risks of other side effects (such as constipation or difficulty passing urine). Check with your healthcare provider before taking oxycodone with an antihistamine, including non-prescription antihistamines.
 
Antipsychotics
Combining an antipsychotic medication with oxycodone can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking oxycodone with an antipsychotic medication.
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