Drug Interactions With Orally Disintegrating Tramadol

When orally disintegrating tramadol is combined with certain drugs, interactions can occur. For example, adverse reactions are possible when the pain medicine is taken with St. John's wort, sibutramine, or warfarin, to name a few. Interactions can increase your risk of potentially serious problems, such as memory loss, extreme drowsiness, and seizures, so make sure your doctor knows about all of your medications before starting treatment.

Orally Disintegrating Tramadol Information

An Introduction to Orally Disintegrating Tramadol Interactions

Orally disintegrating tramadol (Rybix™ ODT) is a prescription pain medication that can potentially interact with a number of other drugs, particularly other medications that cause sedation or that affect serotonin, an important neurotransmitter.

Some of the products that may lead to drug interactions with orally disintegrating tramadol include but are not limited to:

Alcoholic beverages
Carbamazepine (Carbatrol^®, Epitol^®, Equetro^®, Tegretol^®)
Cyclobenzaprine (Flexeril^®, Amrix^®)
Dextromethorphan (a common active ingredient in cough medications)
Digoxin (Digitek^®, Lanoxin^®)
Linezolid (Zyvox^®)
Other medications that cause drowsiness, such as:
- Antipsychotic medications
- Anxiety medications
- Most antidepressants
- Narcotic pain relievers
- Sleep medications
- Some antihistamines

Promethazine (Phenadoz™, Phenergan^®, Promethagan™)
Quinidine
Sibutramine (Meridia^®)
St. John's wort
Triptans, such as:

Almotriptan (Axert^®)
Eletriptan (Relpax^®)
Frovatriptan (Frova^®)
Naratriptan (Amerge^®)
Rizatriptan (Maxalt^®)
Sumatriptan (Alsuma™, Imitrex^®, Sumavel^®) or sumatriptan/naproxen sodium (Treximet^®)
Zolmitriptan (Zomig^®)

Tryptophan
Warfarin (Coumadin^®, Jantoven^®).

Drug Interactions With Orally Disintegrating Tramadol Article Continues on Next Page >