Drug Interactions With Orally Disintegrating Tramadol

Quinidine
The liver metabolizes orally disintegrating tramadol into a substance known as M1 that is responsible for much of the pain-relieving properties of orally disintegrating tramadol. Quinidine interferes with the liver's ability to metabolize orally disintegrating tramadol into M1, which might possibly make the medication less effective.
 
Sibutramine
Taking orally disintegrating tramadol with sibutramine can cause seizures or a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
St. John's Wort
Combining orally disintegrating tramadol with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
Triptans
Taking orally disintegrating tramadol with a triptan can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
Tryptophan
Taking orally disintegrating tramadol with tryptophan can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
Warfarin
There have been rare reports of a possible drug interaction between warfarin and orally disintegrating tramadol. This interaction might increase your risk of bleeding. Check with your healthcare provider before combining these medications; you may need to be monitored more closely.
 
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Orally Disintegrating Tramadol Information

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