Morphine Sulfate

As a type of narcotic, morphine sulfate is an opiate ingredient that can help relieve pain. This drug is found in many prescription pain relievers and is classified as a controlled substance, meaning there are special laws controlling its sale and use. Although most people tolerate it well, there are possible side effects, such as nausea, drowsiness, and constipation.

What Is Morphine Sulfate?

Morphine sulfate is an opiate pain reliever. It is an active ingredient in many different prescription medications. The medication comes in many different forms, such as tablets, extended-release tablets or capsules, oral solution, or injectable solution.
 
Morphine sulfate is a narcotic and is a "controlled substance" in the United States.
 
(Click What Is Morphine Sulfate Used For? for more information, including possible off-label uses.)
 

Side Effects

As with any medicine, morphine sulfate can cause side effects. However, not everyone who takes the drug will experience side effects. Most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider. Serious side effects are less common.
 
Common side effects of morphine sulfate include, but are not limited to:
 
  • Lightheadedness or dizziness
  • Drowsiness
  • Nausea or vomiting
  • Sweating
  • An unusual unpleasant feeling (dysphoria) or an unusual pleasant feeling (euphoria)
  • Constipation (see Morphine and Constipation).
     
(Click Side Effects of Morphine Sulfate to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)
 

Abuse Potential

Morphine sulfate has a significant potential for both psychological and physical dependence and abuse. In fact, it is classified as a controlled substance, meaning that there are special rules and regulations for prescribing and obtaining the medication. Because morphine sulfate can be a desirable drug of abuse, people often try to buy it through illegal means, such as from foreign countries or online sources that do not require a prescription. It is readily available and relatively inexpensive (at least in generic form), making it a popular drug of abuse.
 
For more information, visit the following eMedTV articles:
 

What Should I Tell My Healthcare Provider Before Taking Morphine Sulfate?

You should talk with your healthcare provider prior to taking this medication if you have:
 
  • A history of drug or alcohol dependence
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • Low blood pressure (hypotension)
  • Gallbladder or pancreas disease
  • Lung disease of any sort
  • A head injury or high intracranial pressure
  • Severe abdominal (stomach) pain
  • An underactive thyroid (hypothyroidism)
  • Asthma
  • Addison's disease
  • An enlarged prostate (benign prostatic hypertrophy, or BPH)
  • Seizures or epilepsy
  • Any allergies, including allergies to foods, dyes, or preservatives.
     
Also, let your healthcare provider know if you are:
 
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
(Click Precautions and Warnings With Morphine Sulfate to learn more, including information on who should not take the drug.)
 

Dosing Information

The dose of morphine sulfate that your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • The particular morphine sulfate product
  • The type and dose of other painkillers you have taken
  • The type and severity of your pain
  • How you respond to the medication
  • Other medications you are taking
  • Other medical conditions you may have.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 
(Click Morphine Sulfate Dosage for more information.)
 

Drug Interactions

Morphine sulfate can potentially interact with several other medicines (see Drug Interactions With Morphine Sulfate).
 

What If I Take an Overdose?

An overdose with morphine sulfate can be very dangerous. If you happen to overdose on this medication, seek immediate medical attention.
 
(Click Morphine Overdose for more information.)
 

How Should Morphine Sulfate Be Stored?

Morphine sulfate should be stored at room temperature, away from moisture and heat. Keep this and all other medications out of the reach of children. Because it can be a desirable drug of abuse, make sure to keep it in a safe place.
 

What Should I Do If I Miss a Dose?

Depending on the particular product, this medication is often prescribed "as needed," which means you do not need to take a dose if you do not feel pain. If you forget to take a dose of morphine sulfate and notice significant pain, take your missed dose right away. However, make sure to wait the recommended time before the next dose.
 

How Does It Work?

Morphine sulfate is a narcotic, opiate pain reliever. It binds to opioid receptors throughout the body and produces numerous different effects. These effects include, but are not limited to:
 
  • Pain relief
  • Cough suppression
  • Drowsiness
  • Anxiety relief
  • Unusual unpleasant feelings (dysphoria) or unusual pleasant feelings (euphoria)
  • Decreased breathing (slow or shallow breathing)
  • Certain changes in the circulatory system
  • Slowing of the digestive tract
  • Release of histamine (which often causes itching)
  • Physical dependence.
     

When and How to Take Morphine Sulfate

Some general considerations include the following:
 
  • This medication comes in tablet, capsule, liquid, or injection form. The particular directions for each product can vary substantially, so make sure to refer to the information for your specific morphine sulfate medication.
     
  • When taking morphine sulfate by mouth, it is probably best to take it with food, as it can be upsetting to the stomach.
     
  • Do not drink alcohol while taking this medication.
     
  • For the medication to work properly, it must be taken as prescribed. Do not increase your dose without your healthcare provider's approval. Do not suddenly stop taking morphine sulfate, especially if you have taken it regularly for more than several weeks (see Morphine Withdrawal).
     

Morphine Sulfate Products

There are many different prescription morphine sulfate products available in several different forms (see How Is Morphine Sulfate Supplied? for more information).
 

Generic Morphine Sulfate

Many (but not all) morphine sulfate products are available in generic form (see the specific products within eMedTV.com for further information).
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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