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Zanaflex Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Zanaflex is combined with any of the drugs listed above.
Alcohol can increase the absorption of Zanaflex, possibly increasing the levels of the medication in the blood. Combining alcohol with Zanaflex can cause additive effects, such as increased drowsiness, confusion, memory loss, or difficulty breathing. It is best to avoid alcohol while taking this drug.
Blood Pressure Medications
Zanaflex can lower blood pressure, which could be a problem for people already taking high blood pressure medications. If you are taking any medication for high blood pressure, ask your healthcare provider if it could interact with Zanaflex.
CYP1A2 Inhibitors
The liver metabolizes (breaks down) Zanaflex using an enzyme known as CYP1A2. Other medications can slow down this enzyme, thus delaying the breakdown of Zanaflex. This could lead to high levels of this medication in the blood and may increase the risk of Zanaflex side effects.
Check with your healthcare provider before taking Zanaflex with any CYP1A2 inhibitor medication. Some strong CYP1A2 inhibitors, such as ciprofloxacin and fluvoxamine, should never be combined with Zanaflex.

Final Thoughts

It is possible that not all Zanaflex drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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