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Constipation, nausea, and drowsiness are some of the most commonly reported side effects of Ultram. Those that are less common and may not be related to the medication at all include depression, weight loss, and concentration problems. Some side effects are potentially serious and require immediate medical attention, including seizures, a rapid heart rate, or difficulty breathing.

An Introduction to Ultram Side Effects

Just like any medicine, Ultram® (tramadol hydrochloride) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are easily treated by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with Ultram. Your healthcare provider can discuss a more complete list of Ultram side effects with you.)
 

Common Side Effects of Ultram

Ultram has been studied thoroughly in clinical trials. In these studies, one group of people received the real medication, while another group was given a different pain medication. As a result, it is possible to see what Ultram side effects occurred, how often they appeared, and how they compared to the other medication.
 
In these studies, the most common side effects included:
 
  • Constipation -- in up to 46 percent of people
  • Nausea -- up to 40 percent
  • Dizziness or a spinning sensation (vertigo) -- up to 33 percent
  • Headaches -- up to 32 percent
  • Drowsiness -- up to 25 percent
  • Vomiting -- up to 17 percent
  • Nervousness, shakiness, agitation, or other "overstimulation" problems -- up to 14 percent.
     
Other common side effects of Ultram (occurring in 1 to 13 percent of people) included but were not limited to:
 
  • Itching
  • Weakness
  • Sweating
  • Indigestion or heartburn
  • Dry mouth
  • Diarrhea
  • Hot flashes or flushing
  • Confusion
  • Coordination problems
  • An unusual pleasant feeling (euphoria)
  • Small, pinpoint pupils
  • Sleeping problems
  • Abdominal pain (stomach pain)
  • Loss of appetite
  • Vision problems
  • Frequent urination or difficulty emptying the bladder fully
  • Menopause symptoms.
     
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
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