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Tylox is a prescription pain reliever that contains acetaminophen and oxycodone. It is licensed to treat moderate to moderately severe pain and is either taken "as needed" or on a scheduled basis. Potential side effects include constipation, drowsiness, and nausea. Since Tylox has a high abuse potential, let your healthcare provider know if you have a history of alcohol or drug abuse before starting treatment.

What Is Tylox?

Tylox® (oxycodone/APAP) is a prescription medication approved to treat moderate to moderately severe pain. Like all oxycodone/APAP products, this medication is not appropriate for very severe pain.
Tylox is a narcotic and is classified as a Schedule II controlled substance in the United States. This means that special laws and regulations control its sale and use. Of all legal prescription medications, schedule II controlled substances have the highest abuse potential.
(Click Tylox Uses for more information, including possible off-label uses.)

Who Makes Tylox?

Brand-name Tylox is made by Ortho-McNeil-Janssen Pharmaceuticals, Inc. Generic versions are made by various manufacturers.

How Does It Work?

Tylox contains two different medications that work together to control pain: acetaminophen and oxycodone hydrochloride. Oxycodone is a semi-synthetic, opioid pain reliever. It is chemically related to codeine. Oxycodone is effective at decreasing pain but also causes drowsiness and suppresses the drive to breathe (which is known medically as "respiratory suppression").
Acetaminophen is a pain reliever and fever reducer commonly found in non-prescription medications such as Tylenol®. "APAP" is an acronym for one of the chemical names for acetaminophen. Adding acetaminophen to oxycodone makes both medications more effective at relieving pain and may limit the abuse potential of oxycodone (as the maximum dose of Tylox is often limited by the acetaminophen content).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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