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Skelaxin is a prescription medication used to treat muscle spasms due to injuries or other musculoskeletal problems. This muscle relaxant comes in the form of a tablet and is typically taken three or four times a day. Although most people have no problems when taking Skelaxin, possible side effects can include nausea, dizziness, and drowsiness.

What Is Skelaxin?

Skelaxin® (metaxalone) is a prescription muscle relaxant. It is approved for use in combination with rest, physical therapy, and other treatments for relieving the pain associated with short-term "musculoskeletal conditions," such as muscle spasms due to an injury.
(Click Skelaxin Uses for more information, including possible off-label uses.)

Who Makes It?

Skelaxin is made by Mallinckrodt, Inc., and is marketed and sold by King Pharmaceuticals, Inc.

How Does Skelaxin Work?

It is not clear exactly how Skelaxin helps relieve muscle spasms. However, it is known to work mostly in the central nervous system (the brain and spinal cord), not directly on the muscles.

When and How to Take It

Some general considerations for when and how to take Skelaxin include the following:
  • The medication comes in tablet form. It is usually taken three or four times daily.
  • You can take Skelaxin with or without food, although taking it with food increases the levels of the medication in the blood, which may increase the risk of side effects.
  • For the medication to work properly, it must be taken as prescribed.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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