Back Pain Home > Roxicet Drug Interactions

Taking certain medications in combination with Roxicet may result in dangerous (and even life-threatening) complications. Some of these interactions can increase your risk of side effects, such as difficulty breathing, memory loss, and drowsiness. Other interactions can also cause liver damage or even death. Antidepressants, antihistamines, antipsychotic medications, and barbiturates are among the medications that can lead to drug interactions with Roxicet.

Roxicet Interactions: An Overview

Roxicet™ (oxycodone/APAP) is a prescription pain medicine that can potentially interact with a number of other medications. Some of the medicines that may lead to Roxicet drug interactions include (but are not limited to):
  • Alcoholic beverages
  • Anticholinergic medications, including (but not limited to):



  • Antidepressants
  • Antihistamines (including many prescription and non-prescription medications for allergies, insomnia, and motion sickness)
  • Barbiturates, such as:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Benzodiazepines, such as:





  • Sleep medications.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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