Back Pain Home > Propoxyphene/Acetaminophen Dosage

The recommended dosage of propoxyphene/acetaminophen for Darvocet A500 is one tablet every four hours as needed for pain. For Darvocet-N 50 and Darvocet-N 100, the recommended dose is 100 mg of propoxyphene napsylate and 650 mg of acetaminophen (equal to one Darvocet-N 100 tablet or two Darvocet-N 50 tablets). People with liver or kidney dysfunction usually require a lower dose of this medication.

Dosage of Propoxyphene/Acetaminophen: An Introduction

In November 2010, the United States Food and Drug Administration (FDA) withdrew all medications that contain propoxyphene from the market. It has been determined that the risks of propoxyphene outweigh the possible benefits. In particular, the FDA was concerned about the drug's ability to cause serious changes in the heart rhythm, even at normal doses. Pharmacies will no longer sell this medication, and people who take it should stop and ask their healthcare provider for a more suitable pain medication.
 
The dose of propoxyphene/acetaminophen (Darvocet®) that your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • How you respond to propoxyphene/acetaminophen
  • Other medications you are taking
  • Other medical conditions you may have.
     
As is always the case, do not adjust your dosage unless your healthcare provider specifically instructs you to do so.
 

Dosing for Pain

For Darvocet-N 50 and Darvocet-N 100, the recommended dosage is 100 mg of propoxyphene napsylate and 650 mg of acetaminophen (equal to one Darvocet-N 100 tablet or two Darvocet-N 50 tablets) every four hours as needed for pain.
 
For Darvocet A500, the recommended dosage is 100 mg of propoxyphene napsylate and 600 mg of acetaminophen (one Darvocet A500 tablet) every four hours as needed for pain.
 
For Darvocet-N 100 and Darvocet A500, the maximum recommended dosage is six tablets per day. For Darvocet-N 50, the maximum recommended dosage is 12 tablets per day.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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