Back Pain Home > Propoxyphene/Acetaminophen Dosage

Dosage for Special Situations

If your kidney or liver function is not optimal, your healthcare provider may decide to prescribe a lower propoxyphene/acetaminophen dosage.
If you take other medications containing acetaminophen, it is critical to monitor your total acetaminophen intake. The maximum recommended dose of acetaminophen for healthy people is 4000 mg per day. Higher doses of acetaminophen increase the risk of serious liver damage. Make sure to watch for any other sources of acetaminophen, including other prescription pain relievers and many over-the-counter products, such as Tylenol®. To be safe, all other acetaminophen products should be avoided while you are taking propoxyphene/acetaminophen, unless you are extremely careful to limit your total acetaminophen use (from all sources added together) to 4000 mg per day.


Propoxyphene/acetaminophen tablets are available in the following strengths:

General Information on Dosing With Propoxyphene/Acetaminophen

Considerations for people taking propoxyphene/acetaminophen include the following:
  • This medication comes in tablet form. It is taken by mouth, often every four hours as needed for pain.
  • It is probably best to take propoxyphene/acetaminophen with food, as it can be upsetting to the stomach.
  • Do not drink alcohol while taking this medication (see Darvocet and Alcohol).
  • For the medication to work properly, it must be taken as prescribed. Do not increase your dose without your healthcare provider's approval. Do not suddenly stop taking propoxyphene/acetaminophen, especially if you have taken it regularly for more than several weeks (see Darvocet Withdrawal).
  • If you are unsure about anything related to your propoxyphene/acetaminophen dosage, please talk with your doctor, nurse, or pharmacist. Do not stop taking the drug without first discussing it with your healthcare provider.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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