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More Information on Drug Interactions With Methocarbamol

The following sections explain in detail the potentially negative interactions that can occur when methocarbamol is combined with any of the drugs listed above.
 
Alcohol
Combining alcohol with methocarbamol can cause additive effects, such as increased drowsiness, confusion, memory loss, or difficulty breathing. It is best to avoid alcohol while taking this medication.
 
Barbiturates
Taking a barbiturate with methocarbamol can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Make sure to talk to your healthcare provider before combining these medications.
 
Benzodiazepines
Combining methocarbamol with a benzodiazepine can cause additive effects, such as increased drowsiness, confusion, memory loss, or difficulty breathing. Make sure to talk to your healthcare provider before taking these drugs together.
 
Narcotics or Opiates
Combining an opiate or narcotic with methocarbamol can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Make sure to talk to your healthcare provider before taking these medicines together.
 
Pyridostigmine
Methocarbamol may make pyridostigmine less effective. Check with your healthcare provider before using these medications together. In some cases, methocarbamol may not be a good choice for people taking pyridostigmine.
 
Sleep Medications
Taking a sleep medication with methocarbamol can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Make sure to talk to your healthcare provider before combining these two medications.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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