Back Pain Home > Drug Interactions With Fentanyl Patch
Drug Interactions With the Fentanyl Patch ExplainedThe following sections explain in detail the potentially negative reactions that can occur when a fentanyl patch is combined with any of the drugs listed above.
Consuming alcohol while using fentanyl patches could potentially increase your risk for serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing. Do not drink alcohol while using this skin patch.
Fentanyl patches may increase the risk for serious alvimopan side effects. You should not take alvimopan if you have used a fentanyl patch in the past seven days.
Combining amphetamines with fentanyl patches may increase the pain-relieving effects of the patch. Your healthcare provider may monitor your response to fentanyl patches if you use these medications together. You might need a lower dose of the fentanyl patch.
Using fentanyl patches with a beta blocker may cause your heart rate and blood pressure to decrease to potentially unsafe levels. If you use these medications together, your healthcare provider may need to closely monitor your blood pressure and heart rate.
Calcium Channel Blockers
Using fentanyl patches with certain calcium channel blockers may cause your heart rate and blood pressure to decrease to potentially unsafe levels. Your healthcare provider may need to closely monitor your blood pressure and heart rate if you use these medications together.
CYP 3A4 Inducer Medications
The body breaks down fentanyl using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inducers) can increase the activity of these enzymes. Combining fentanyl patches with one of these CYP 3A4 inducers may decrease the level of fentanyl in your body, making it less effective. Your healthcare provider may need to monitor you more closely to make sure your pain is adequately controlled if you use a fentanyl patch with a CYP 3A4 inducer.