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Acetaminophen with codeine is a prescription medicine licensed to treat mild to moderate pain. It comes in tablet and oral solution form, and is generally taken every four hours as needed for pain. The codeine component of the combination drug is effective at decreasing pain and relieving coughing, but it is also a narcotic, opioid pain reliever. Therefore, the medication is classified as a controlled substance.

What Is Acetaminophen With Codeine?

Acetaminophen with codeine (Tylenol® with Codeine) is a prescription pain medication approved to treat mild to moderate pain. Because it contains codeine, a narcotic, acetaminophen with codeine is classified as a controlled substance, which means that special regulations and laws control its sale and use.
(Click What Is Acetaminophen With Codeine Used For? for more information, including possible off-label uses.)

Are There Side Effects?

As with any medicine, acetaminophen with codeine can cause side effects. However, not everyone who takes the drug will experience side effects. Most people tolerate it quite well.
If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. Serious side effects are less common.
Common side effects of acetaminophen with codeine include, but are not limited to:
  • Nausea
  • Vomiting
  • Constipation
  • Lightheadedness
  • Dizziness
  • Drowsiness.
(Click Side Effects of Acetaminophen with codeine to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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