Hydrocodone Drug Interactions

Hydrocodone could interact negatively with a number of other medications. For example, drug interactions may occur if the narcotic is taken together with barbiturates, antihistamines, benzodiazepines, or antipsychotic medicines. These drug interactions with hydrocodone can increase your risk for developing side effects, such as drowsiness, confusion, memory loss, or difficulty breathing.

Hydrocodone Interactions: An Overview

Hydrocodone can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with hydrocodone include:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Benzodiazepines, such as:



Alternative Therapies for Pain Management

Hydrocodone Medication Information

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