Hydrocodone Drug Interactions

Barbiturates
Combining a barbiturate with hydrocodone can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking hydrocodone with a barbiturate.
 
Benzodiazepines
Taking hydrocodone in combination with a benzodiazepine might increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Talk to your healthcare provider before taking hydrocodone with any benzodiazepines.
 
Other Narcotics or Opiates
Use extreme caution when combining hydrocodone with other narcotics or opiates, as serious side effects could occur. You should only use these medications together with your healthcare provider's approval and supervision.
 
Sleep Medications
Hydrocodone can cause significant drowsiness, and combining it with a sleep medication could lead to dangerous effects. In general, hydrocodone should not be used in combination with sleep medications, unless your healthcare provider specifically recommends that you do so.
 

Final Thoughts

It is possible that not all drug interactions with hydrocodone were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific hydrocodone drug interactions that may apply to you.
 
Alternative Therapies for Pain Management

Hydrocodone Medication Information

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