Flexeril Warnings and Precautions

It is important to review Flexeril warnings and precautions with your healthcare provider before starting the medication. For example, tell your healthcare provider about any existing medical conditions you have and any other medications you are taking. Other warnings and precautions with Flexeril include the safety of taking the drug if you have liver disease and the risk of the medication causing certain side effects.

Flexeril: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Flexeril® (cyclobenzaprine hydrochloride) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Flexeril Warnings and Precautions

Some warnings and precautions to be aware of prior to taking Flexeril include the following:
  • If you have liver disease, your healthcare provider may recommend a lower or less frequent Flexeril dosage, because your body may not handle Flexeril as well as usual. Depending on the severity of your liver disease, your healthcare provider may recommend that you do not take Flexeril.
  • Flexeril commonly causes drowsiness and dizziness, which may interfere with your ability to drive a car, operate heavy machinery, or focus mentally. Even if you take Flexeril just at bedtime, you may experience a hangover-like effect in the morning.
  • Check with your healthcare provider before taking Flexeril if you have glaucoma (an eye condition) or difficulty passing urine, as Flexeril can make these conditions worse.
  • Flexeril can potentially interact with many other medications (see Flexeril Interactions).
  • Flexeril may increase the risk of a potentially dangerous group of symptoms known as serotonin syndrome, especially when used in combination with certain other medications. These symptoms include:
    • Confusion
    • Hallucination
    • Fast heartbeat
    • Feeling faint
    • Fever
    • Sweating
    • Muscle spasm
    • Difficulty walking
    • Diarrhea.
Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous. 
  • Flexeril is considered a pregnancy Category B medication. This means that it is probably safe for use during pregnancy, although the full risks are not currently known (see Flexeril and Pregnancy).
  • It is not known if Flexeril passes through breast milk in humans. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Flexeril and Breastfeeding).
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