Flexeril Interactions

When certain medications are taken with Flexeril, drug interactions may occur. These reactions could increase your risk for side effects, including drowsiness, confusion, memory loss, or difficulty breathing. Other interactions could cause more serious side effects, such as seizures or life-threatening problems. Some of the medications that can interfere with Flexeril include alcohol, anesthetics, and MAOIs.

An Overview of Interactions With Flexeril

Flexeril® (cyclobenzaprine hydrochloride) can potentially interact with several other medications. Some of these medicines that may lead to drug interactions with Flexeril include:
  • Alcohol
  • Anesthetics
  • Anticholinergic medications, including:



  • Barbiturates, including:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)


  • Benzodiazepines, including:






5 Common Pain Medication Fears

Flexeril Drug Information

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