Flexeril Interactions

When certain medications are taken with Flexeril, drug interactions may occur. These interactions could increase your risk for side effects, including drowsiness, confusion, memory loss, or difficulty breathing. Other interactions could cause more serious side effects, such as seizures or life-threatening problems. Some of the medications that can lead to negative Flexeril interactions include alcohol, anesthetics, and MAOIs.

 

An Overview of Flexeril Interactions

Flexeril® (cyclobenzaprine hydrochloride) can potentially interact with several other medications. Some of these medicines that may lead to Flexeril drug interactions include:
 
  • Alcohol
  • Anesthetics
  • Anticholinergic medications, including:

 

 

  • Barbiturates, including:

 

    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)

 

  • Benzodiazepines, including:

 

 

  • Monoamine oxidase inhibitors (MAOIs), including:

 

 

  • Narcotics or opiates, such as morphine, oxycodone (OxyContin®), or hydrocodone (Lortab®, Vicodin®)
  • Sleep medications
  • Tramadol (Ultram®) or tramadol and acetaminophen (Ultracet®).
     
(Flexeril Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;