Flexeril Interactions

When certain medications are taken with Flexeril, drug interactions may occur. These reactions could increase your risk for side effects, including drowsiness, confusion, memory loss, or difficulty breathing. Other interactions could cause more serious side effects, such as seizures or life-threatening problems. Some of the medications that can interfere with Flexeril include alcohol, anesthetics, and MAOIs.

• Alcohol
• Anesthetics
• Anticholinergic medications, including:

• • Atropine
  • Belladonna (Donnatal^®, B&O Supprettes^®, Bellamine S^®)
  • Benztropine (Cogentin^®)
  • Clidinium (Librax^®)
  • Clozapine (Clozaril^®)
  • Darifenacin (Enablex^®)
  • Dicyclomine (Bentyl^®)
  • Diphenhydramine (Benadryl^®, Tylenol PM^®)
  • Glycopyrrolate (Robinul^®)
  • Haloperidol (Haldol^®)
  • Homatropine (Hycodan^®)
  • Hyoscyamine (Levsin^®)
  • Ipratropium (Atrovent^®)
  • Scopolamine (Transderm Scop^®)
  • Tiotropium (Spiriva^®)
  • Tolterodine (Detrol^®)
  • Trospium (Sanctura^®)

• Barbiturates, including:

• • Amobarbital (Amytal^®)
  • Butalbital (Fioricet^®, Fiorinal^®)
  • Pentobarbital (Nembutal^®)
  • Phenobarbital (Luminal^®)
  • Secobarbital (Seconal^®)

• Benzodiazepines, including:

• • Alprazolam (Xanax^®, Xanax^® XR)
  • Chlordiazepoxide (Librium^®, Limbitrol^®, Librax^®)
  • Clonazepam (Klonopin^®)
  • Clorazepate (Tranxene^®)
  • Diazepam (Valium^®)
  • Estazolam (ProSom^®)
  • Flurazepam (Dalmane^®)
  • Lorazepam (Ativan^®)
  • Midazolam (Versed^®)
  • Temazepam (Restoril^®)
  • Triazolam (Halcion^®)

• Certain antidepressants or fibromyalgia medications, such as:
  • Miscellaneous antidepressants, such as:
    • Bupropion (Aplenzin™, Budeprion XL^®, Budeprion™ SR, Buproban^®, Wellbutrin SR^®, Wellbutrin XL^®, Wellbutrin^®, Zyban^®)
    • Mirtazapine (Remeron^®)
    • Nefazodone (Serzone^®)
    • Trazodone (Desyrel^®) or trazodone ER (Oleptro™)
    • Vilazodone (Viibryd™)
  • Selective serotonin reuptake inhibitor (SSRI) or serotonin norepinephrine reuptake inhibitor (SNRI) medications, such as:
    • Citalopram (Celexa^®)
    • Duloxetine (Cymbalta^®)
    • Desvenlafaxine (Pristiq^®)
    • Escitalopram (Lexapro^®)
    • Fluoxetine (Prozac^®, Sarafem^®, Selfemra™)
    • Fluvoxamine (Luvox^®, Luvox^® CR)
    • Levomilnacipran (Fetzima™)
    • Milnacipran (Savella™)
    • Paroxetine (Paxil^®, Paxil CR^®, Pexeva^®, Brisdelle™)
    • Sertraline (Zoloft^®)
    • Venlafaxine (Effexor^®, Effexor XR^®)
  • Tricyclic antidepressants, such as:
    • Amitriptyline (Elavil^®)
    • Amoxapine (Asendin^®)
    • Clomipramine (Anafranil^®)
    • Desipramine (Norpramin^®)
    • Doxepin (Sinequan^®, Silenor^®)
    • Imipramine (Tofranil^®, Tofranil PM^®)
    • Maprotiline (Ludiomil^®)
    • Nortriptyline (Pamelor^®)
    • Protriptyline (Vivactil^®)
    • Trimipramine (Surmontil^®)
• Meperidine (Demerol^®) 
• Monoamine oxidase inhibitors (MAOIs), including:

• • Isocarboxazid (Marplan^®)
  • Phenelzine (Nardil^®)
  • Rasagiline (Azilect^®)
  • Selegiline (Eldepryl^®, Emsam^®, Zelapar^®)
  • Tranylcypromine (Parnate^®)

• Narcotics or opiates, such as morphine, oxycodone (OxyContin^®), or hydrocodone (Lortab^®, Vicodin^®)
• Sleep medications

• Tramadol (Rybix™ ODT, Ryzolt^®, Ultram^®, Ultram^® ER) or tramadol/acetaminophen (Ultracet^®)
• Verapamil (Calan^®, Calan SR^®, Covera-HS^®, Isoptin SR^®, Verelan^®, Verelan PM^®)