Flexeril Interactions (Cont.)

 
Narcotics or Opiates
Combining an opiate or narcotic with Flexeril can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk to your healthcare provider before taking Flexeril with an opiate or narcotic.
 
Sleep Medications
Combining a sleep medication with Flexeril can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk to your healthcare provider before taking Flexeril with a sleep medication.
 
Tramadol (Ultram) or Tramadol and Acetaminophen (Ultracet)
In general, it is not recommended to take Flexeril and tramadol together, as this may increase your risk of seizures.
 

Final Thoughts on Flexeril Interactions

It is possible that not all Flexeril drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions with Flexeril that may apply to you.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;