Flexeril Interactions

Monoamine Oxidase Inhibitors (MAOIs)
Do not take Flexeril and a MAOI together (or within two weeks of each other), as combining these medications can cause life-threatening problems.
 
Narcotics or Opiates
Combining an opiate or narcotic with Flexeril can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk to your healthcare provider before taking Flexeril with an opiate or narcotic.
 
Sleep Medications
Combining a sleep medication with Flexeril can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk to your healthcare provider before taking Flexeril with a sleep medication.
 
Tramadol or Tramadol and Acetaminophen 
In general, it is not recommended to take Flexeril and tramadol together, as this may increase your risk of seizures. In addition, this combination may also increase the risk of serotonin syndrome.
 
Verapamil
Taking verapamil and Flexeril together may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 

Final Thoughts

It is possible that not all drug interactions with Flexeril were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
 
 
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