Fentanyl Patch Side Effects

Common Side Effects

The fentanyl patch has been studied extensively in clinical trials with children and adults. In these studies, the side effects that occurred in a group of people using the patches were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
The most common side effects of fentanyl patches, occurring in more than 10 percent of people in clinical trials, included:
  • Nausea
  • Vomiting
  • Constipation
  • Dry mouth
  • Drowsiness
  • Confusion
  • Weakness
  • Sweating.
Other common fentanyl patch side effects, occurring in 3 to 10 percent of people, included:
  • Abdominal (stomach) pain
  • Headaches
  • Fatigue
  • Flu-like symptoms (such as fever, aches, and chills)
  • Loss of appetite
  • Diarrhea
  • Indigestion or heartburn
  • Dizziness
  • Difficulty sleeping (which may be more common in children)
  • An exaggerated sense of well-being (euphoria)
  • Infections of the upper respiratory tract
  • Sore throat
  • Itching
  • Problems urinating
  • Pain and redness at the application site.

Final Thoughts

You may experience some or none of the side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while using fentanyl patches or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.
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