Drug Interactions With Fentanyl Patch

Potentially dangerous complications could occur if you take certain medications in combination with the fentanyl patch. Some of these drug interactions can increase your risk of side effects, such as difficulty breathing, memory loss, and dangerously low blood pressure. Alcohol, amphetamines, antipsychotic medications, and beta blockers are among the medications that can lead to negative reactions with the fentanyl patch.

An Overview of Fentanyl Patch Interactions

The
 fentanyl patch (Duragesic®) can potentially interact with several other medications (since some of the medication is absorbed into the bloodstream).
 
Some of the medications that may lead to interactions with the patch include but are not limited to:
 
  • Alcohol
  • Alvimopan (Entereg®)
  • Amphetamines or amphetamine-like medications, such as:
 
 
 
 
 
 
  • CYP 3A4 inducer medications, such as:
 
 
  • CYP 3A4 inhibitor medications, such as:
 
 
  • Desmopressin (DDAVP®, Minirin®, Stimate®)
  • Grapefruit juice
  • Medications that cause drowsiness, such as:
 
 
  • Monoamine oxidase inhibitors (MAOIs), such as:
 
 
  • Octreotide (Sandostatin®)
  • Pegvisomant (Somavert®)
  • Thiazide diuretics (and thiazide-like diuretics), such as:
 
 
Drug Interactions With Fentanyl Patch Article Continues on Next Page >
Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD
 
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