Drug Interactions With Fentanyl Patch

CYP 3A4 Inhibitor Medications
The body breaks down fentanyl using enzymes in the liver known as CYP 3A4 enzymes. Some other medications (known as CYP 3A4 inhibitors) can decrease the activity of these enzymes. Combining fentanyl patches with one of these CYP 3A4 inhibitors may increase the level of fentanyl in your body, increasing your risk for serious side effects, including drowsiness, confusion, and difficulty breathing. Your healthcare provider may monitor you more closely for side effects if you use a fentanyl patch with a CYP 3A4 inhibitor.
 
Desmopressin
Fentanyl patches can increase the risk for desmopressin side effects. Talk to your healthcare provider prior to using these medications together.
 
Grapefruit Juice
Grapefruit juice may increase the amount of fentanyl in your blood, potentially increasing your risk for serious side effects, such as drowsiness, confusion, and breathing problems. Talk to your healthcare provider before eating grapefruit or drinking grapefruit juice while you are using fentanyl patches.
 
Medications That Cause Drowsiness
The fentanyl patch causes significant drowsiness. Taking other medications that cause drowsiness while using fentanyl patches may lead to serious side effects, such as extreme sedation, low blood pressure, confusion, and serious breathing problems. Check with your healthcare provider before using this skin patch with other medications that can cause drowsiness.
 
Monoamine Oxidase Inhibitors (MAOIs)
Combining fentanyl patches with an MAOI may potentially cause a serious reaction known as serotonin syndrome. It can also lead to low blood pressure. Do not use fentanyl patches if you have taken an MAOI within the past 14 days.
 
Octreotide
Combining octreotide with a fentanyl patch may increase the pain-relieving effects of the skin patch. Your healthcare provider may monitor your pain response if you use these medications together. You might need a lower dose of the fentanyl patch.
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