Side Effects of Acetaminophen With Codeine

Abdominal pain, vomiting, and lightheadedness are some of the common side effects that may occur with acetaminophen with codeine. Side effects of the medication are generally mild and either do not require medical attention or can be treated easily. However, some side effects of acetaminophen with codeine are potentially serious and should be reported to your healthcare provider immediately, including anxiety, severe drowsiness, or confusion.

An Introduction to Acetaminophen With Codeine Side Effects

As with any medicine, acetaminophen with codeine (Tylenol® with Codeine) can cause side effects. However, not everyone who takes the medication will experience side effects. Most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with acetaminophen with codeine. Your healthcare provider can discuss a more complete list of acetaminophen with codeine side effects with you.)

Serious Side Effects Seen With Acetaminophen With Codeine

Some side effects with acetaminophen with codeine, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include, but are not limited to:
  • Signs of liver damage (due to the acetaminophen component of acetaminophen with codeine), such as:


    • Yellowing of the whites of the eyes or skin (jaundice)
    • Upper-right abdominal pain (stomach pain)
    • Dark urine


  • Very severe constipation
  • Slow or irregular breathing
  • Low blood pressure (hypotension)
  • Severe drowsiness or loss of consciousness
  • The urge to take more acetaminophen with codeine than prescribed or for a non-medical purpose
  • Confusion
  • Anxiety or fear
  • Loss of balance or falling
  • A slow heart rate (bradycardia)
  • Difficulty passing urine
  • Signs of an allergic reaction, such as:


    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.


5 Common Pain Medication Fears

Info on Acetaminophen With Codeine

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